The Department of Theoretical Biology uses mathematics and computer simulations to study the dynamics of evolution. Our team is interdisciplinary, with backgrounds ranging from biology, physics, and mathematics to computer science and economics. Our goal is, on the one hand, to model biological systems with a close connection to empirical research, on the other hand we develop the mathematical toolbox of theoretical biology further and aim to generate new conceptual insights. The biological problems we address include the emergence and maintenance of polymorphisms in natural populations, the evolution of cooperation and the evolutionary dynamics of cancer.
The department is organised into the three main themes Cancer Evolution, Metaorganisms, and Population Structure and Game Theory. In addition, the department is hosting four research groups, which independently pursue their own research directions.
Cancer Evolution
The accumulation of mutations within the cells of a tissue can be viewed as an evolutionary process. We use mathematical and computational models to gain insights into the dynamics of these processes. In collaboration with clinicians, experimentalists and bioinformaticians, we have so far mostly focussed on blood diseases, but several general insights can be used to construct theoretical models for other systems.
Metaorganisms
Why do individuals from different taxonomic groups and even kingdoms of life interact with each other within a metaorganism in a generally beneficial way and thereby form a unit of selection? This question is one of the most fascinating, unresolved mysteries in current evolutionary biology. We develop mathematical models to understand interactions within the metaorganism in close collaboration with the CRC 1182 Origin and Function of Metaorganisms.
Population Structure
and
Game Theory
While the evolution of cooperation is the most popular topic in evolutionary game theory, the game theoretical approach offers much more to evolutionary biology. We are interested in eco-evoluionary dynamics under frequency and density dependent selection, in the evolution of multicellular units, but also in the general role that population structure (in terms of groups, networks or age) plays for evolutionary dynamics.
Research Group
Microbial Evolutionary Dynamics
In the Microbial Evolutionary Dynamics group, we use bacterial and phage populations to empirically investigate fundamental evolutionary processes. Our over-arching theme is the evolution and maintenance of genetic structure – how and why particular genetic entities come to exist.
Dr. Jenna Gallie
Research Group
Theoretical Models of Eco-evolutionary Dynamics
Evolution proceeding at ecological time scales changes the way we approach traditional evolutionary dynamics. We are interested in understanding the evolutionary change in interactions in the light of the ecology in which they take place.
Chaitanya is now a Professor at the University of Würzburg, but will maintain his group at the Max Planck Institute for Evolutionary Biology.
Prof. Dr. Chaitanya Gokhale
Research Group
Stochastic Evolutionary Dynamics
Our research lies at the intersections of evolution with ecology and with medicine. Using mathematical models, we study which factors promote or hamper rapid adaptation to changing environments.
Dr. Hildegard Uecker
Research Group
Dynamics of Microbial Collectives
Microbial ecology often deploys in the context of collectives -- communities, biofilms, multicellular aggregates. We inquire how the properties of such collectives emerge and evolve based on cellular-level mechanisms.
Dr. Silvia De Monte
Research Group
Molecular Systems Evolution
Our research aims at understanding the evolution of genomes. By comparing genome sequences from various individuals and/or species, one can gain insights into the process of how and when species are created. We combine modeling approaches and statistical data analysis, as well as lab experiments when possible.
Prof. Dr. Julien Dutheil
The Team
Alumni
Opportunities
General advice
We are an interdisciplinary department and people working here have backgrounds ranging from theoretical physics and computer science to biology and medicine. The combination of different skillsets is crucial for the success of our work. A central aspect in this is that applicants are highly motivated to do research in our department. Thus, please let us know in your application why our department seems to be the right place for you and why you are the right person for us! How did you hear about us? Which papers did you read? Did someone inspire you? Tell us about the path that led you to your interest in the department! Do you already have a concrete project in mind that you would like to work on? Or are you interested in the general area? In the end, there must be the right match on both sides - you need to be sure that this is the place to develop your career further and we need to be sure that you will fit in scientifically and as a person!
Formalities
If you apply for a job at the MPI Plön, please send
- Your CV, including a publication list and contact details of at least two references.
- A letter of motivation why you are interested in joining the department.
How to join the department
There are two tracks to join our department:
- If you want to work with Arne Traulsen as a PhD candidate or PostDoc, please inquire directly:
traulsen@evolbio.mpg.de
- Applicants interested in joining one of the independent departmental research groups instead should directly contact Dr. Jenna Gallie, Prof. Julien Dutheil, Dr. Hildegard Uecker, or Dr. Silvia De Monte.
The selection force weakens with age because ageing evolves and not vice versa
Eco-evolutionary dynamics of clonal multicellular life cycles
The impact of phenotypic heterogeneity of tumour cells on treatment and relapse dynamics
